何张江，男，1985年9月出生，博士（博士后），副教授，硕士研究生导师。2016年博士毕业于西南大学微生物学专业，获博士学位，2017年1月至2018年12月于西南大学植物保护学科从事博士后研究工作。2019年4月入职贵州大学。从事真菌与植物互作关系等领域的研究。内容包括：1）内生砖红镰刀菌定殖特性与免疫；2）内生菌免疫因子与内生机制；3）内生菌形态转化与菌植互作机制；4）内生菌状态转换的机理；5）内生菌与植物根系土壤、菌群、促生抗病；6）内生菌“植物疫苗”制剂开发及推广。以第一作者或通讯作者身份在BMC Biology、Environmental Microbiology、Applied Microbiology and Biotechnology、Journal of Invertebrate pathology 和 Fungal Genetics and biology 等 SCI学术刊物上发表论文30余篇，主持国家自然科学基金项目2项，贵州省自然科学基金1项，申请获发明专利8项。

近年来发表论文：

1. He, Z., Zhang, S., Keyhani, N.O., Song, Y., Huang, S., Pei, Y., and Zhang, Y. (2015) A novel mitochondrial membrane protein, Ohmm, limits fungal oxidative stress resistance and virulence in the insect fungal pathogen Beauveria bassiana. Environ Microbiol 17:4213-4238.

2. He, Z., Zhao, X., Lu, Z., Wang, H., Liu, P., Zeng, F., and Zhang, Y. (2018). Comparative transcriptome and gene co-expression network analysis reveal genes and signaling pathways adaptively responsive to varied adverse stresses in the insect fungal pathogen, Beauveria bassiana. J. Invertebr. Pathol. 151, 169–181.

3. He, Z., Luo, L., Keyhani, N.O., Yu, X., Ying, S., and Zhang, Y. (2017). The C-terminal MIR-containing region in the Pmt1 O-mannosyltransferase restrains sporulation and is dispensable for virulence in Beauveria bassiana. Appl Microbiol Biot 101, 1143–1161

4. Wang, H#., He, Z#., Luo, L., Zhao, X., Lu, Z., Luo, T., Li, M., and Zhang, Y. (2018). An aldo-keto reductase, Bbakr1, is involved in stress response and detoxification of heavy metal chromium but not required for virulence in the insect fungal pathogen, Beauveria bassiana.Fungal Genet and Biol 111, 7–15.

5. He,Z., Zhao, X., Gao, Y.,Keyhani, N.O., Wang, H., Deng, J., Lu, Z., Kan, Y., Luo, Z. and Zhang, Y.(2020) The fungal mitochondrial membrane protein, BbOhmm, antagonistically controls hypoxia tolerance. Environ Microbiol. 22(7), 2514–2535. doi: 10.1111/1462-2920.14910.  

6. He Z., Song Y., Deng J., Zhao X., Qin X.,Luo Z. and Zhang Y. (2020) Participation of a MADS-box transcription factor,Mb1, in regulation of the biocontrol potential in an insect fungal pathogen. J. Invertebr. Pathol. 170, 107335

7. Qin, M., Li, Y., Cai, L., Yin, X., He, Z., and Kang, J. (2022). Overexpression of the global regulator FnVeA upregulates antitumor substances in endophytic Fusarium nematophilum. Canadian journal of microbiology, 68(8), 531–541.

8. Cai, L. , Wang, J. , Li, Y. , Qin, M. , Yin, X. , He, Z. , Kang, J. (2022). Global regulatory factor vea upregulates the production of antitumor substances in endophytic Fusarium solani. Antonie van Leeuwenhoek, 115(8), 1085-1100.

9. Yin, X., Han, L., Zheng, W., Cai, L., Qin, M., He, Z. and Kang, J. (2022). Global regulatory factor AaLaeA upregulates the production of antitumor substances in the endophytic fungus Alternaria alstroemeria. Journal of basic microbiology, 62(11):1402-1414. 10.1002/jobm.202200391.

10. Zeng, X., Qian, S., Lu, Y., Li, Y., Cheng, L., Qian, Y., He, Z. and Kang, J. (2022) A Novel Nitrogen-containing Glyceride from Fungal Saprobe Tubeufia rubra Reverses MDR of Tumor Cell Lines to Doxorubicin. Records of natural products. 16, 622–632. 10.25135/rnp.320.2201.2334

11. Feng, C., Zheng, W., Han, L., Wang, J. K., Zha, X. P., Xiao, Q., He, Z. J., & Kang, J. C. (2023). AaLaeA targets AaFla1 to mediate the production of antitumor compound in Alternaria alstroemeria. Journal of basic microbiology, 64(1), 68–80 10.1002/jobm.202300319. Advance online publication.

12. Liu, G., Wang, J., Zheng, W., Han, L., Huang, J., He, Z., & Kang, J. (2023). Nanoemulsion of the Essential Oil from Blumea balsamifera (L.) DC. and Its Effect on Trauma Repair. Journal of oleo science, 72(9), 869–879.

13. Han, L., Zheng, W., Qian, S. Y., Yang, M. F., Lu, Y. Z., He, Z. J., & Kang, J. C. (2023). New Guaiane-Type Sesquiterpenoids Biscogniauxiaols A-G with Anti-Fungal and Anti-Inflammatory Activities from the Endophytic Fungus Biscogniauxia Petrensis. Journal of fungi (Basel, Switzerland), 9(4), 393.

14. Zheng, W., Han, L., He, Z. J., & Kang, J. C. (2023). A new alkaloid derivative from the saprophytic fungus Neohelicomyces hyalosporus PF11-1. Natural product research, 1–5. Advance online publication.

15. Huang, J., He, Z., Wang, J., Zha, X., Xiao, Q., Liu, G., Li, Y., & Kang, J. (2023). A Novel Effector FlSp1 Inhibits the Colonization of Endophytic Fusarium lateritium and Increases the Resistance to Ralstonia solanacearum in Tobacco. Journal of fungi (Basel, Switzerland), 9(5), 519.

16. Qian, S., Zeng, X., Qian, Y., Lu, Y., He, Z., & Kang, J. (2023). A Saprophytic Fungus Tubeufia rubra Produces Novel Rubracin D and E Reversing Multidrug Resistance in Cancer Cells. Journal of fungi (Basel, Switzerland), 9(3), 309.

17. Zhao, X., He, Z., Gao, Y., Kan, Y., Jiao, Y., Liu, Y., Huang, S., Luo, Z., & Zhang, Y. (2023). Sterol Regulatory Element-Binding Protein, BbSre1, Controls Oxidative Stress Response, Peroxisome Division, and Lipid Homeostasis in an Insect Fungal Pathogen. Journal of agricultural and food chemistry, 71(32), 12250–12263.

18. Kan, Y., He, Z., Keyhani, N. O., Li, N., Huang, S., Zhao, X., Liu, P., Zeng, F., Li, M., Luo, Z., & Zhang, Y. (2024). A network of transcription factors in complex with a regulating cell cycle cyclin orchestrates fungal oxidative stress responses. BMC biology, 22(1), 81.

主持的项目：

1. 国家自然科学基金，内生砖红镰刀菌介导番茄生长素平衡的分子基础研究，35万元，2022.01-2025.12，32160667，在研，主持

2. 国家自然科学基金，球孢白僵菌甾醇调控元件结合蛋白 SrbA 介导氧化胁迫反应的机制，25万元，2020.01-2022.12，31901947，在研，主持

3. 贵州省科学基金，一株内生砖红镰刀菌介导马铃薯促生抗病的分子基础研究，10万元，2021.01-2023.12，黔科合基础-ZK[2021]一般 145，在研，主持

4. 贵州大学培育项目 ，内生砖红镰刀菌小孢子的生物学功能研究，5.5万元，2021.09-2024.09，贵大培育【2020】19号，在研，主持

5. 贵州大学博士基金，线粒体膜蛋白Ohmm负介导白僵菌适应昆虫体内低氧的机制，3.5万元，2020.01-2022.12，贵大人基合字（2019）71号，在研，主持

文字：何张江

一审：钱欣荣   一校：杨兴变

二审：李  林   二校：易  琼

三审：康冀川   三校：雷帮星